“CLipP”ing on lipids to generate antibacterial lipopeptides
نویسندگان
چکیده
منابع مشابه
Sustained Release of Antibacterial Lipopeptides from Biodegradable Polymers against Oral Pathogens
The development of antibacterial drugs to overcome various pathogenic species, which inhabit the oral cavity, faces several challenges, such as salivary flow and enzymatic activity that restrict dosage retention. Owing to their amphipathic nature, antimicrobial peptides (AMPs) serve as the first line of defense of the innate immune system. The ability to synthesize different types of AMPs enabl...
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A lot of crops are destroyed by the phytopathogens such as fungi, bacteria, and yeast leading to economic losses to the farmers. Members of the Bacillus genus are considered as the factories for the production of biologically active molecules that are potential inhibitors of growth of phytopathogens. Plant diseases constitute an emerging threat to global food security. Many of the currently ava...
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This Feature Article discusses several classes of lipopeptide with important biomedical applications as antimicrobial and antifungal agents, in immune therapies and in personal care applications among others. Two main classes of lipopeptide are considered: (i) bacterially-expressed lipopeptides with a cyclic peptide headgroup and (ii) linear lipopeptides (with one or more lipid chains) based on...
متن کاملA new group of antifungal and antibacterial lipopeptides derived from non-membrane active peptides conjugated to palmitic acid.
We report on the synthesis, biological function, and a plausible mode of action of a new group of lipopeptides with potent antifungal and antibacterial activities. These lipopeptides are derived from positively charged peptides containing d- and l-amino acids (diastereomers) that are palmitoylated (PA) at their N terminus. The peptides investigated have the sequence K(4)X(7)W, where X designate...
متن کاملVisualization Based on Interactive Clipping: Application to Confocal Data
ii Acknowledgements I would like to express my sincere gratitude to Dr. Bijaya B. Karki, my advisor, for his invaluable guidance and encouragement extended throughout the study. His tenacious supervision, helpful suggestion, patience and time deserve a special mention. I have learnt the basics of scientific visualization under his guidance and would like to acknowledge his command in this area ...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2020
ISSN: 2041-6520,2041-6539
DOI: 10.1039/d0sc01814g